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Capture and Stimulated Release of Circulating Tumor Cells on Polymer‐Grafted Silicon Nanostructures
Author(s) -
Hou Shuang,
Zhao Haichao,
Zhao Libo,
Shen Qinglin,
Wei Kevin S.,
Suh Daniel Y.,
Nakao Aiko,
Garcia Mitch A.,
Song Min,
Lee Tom,
Xiong Bin,
Luo ShyhChyang,
Tseng HsianRong,
Yu Hsiaohua
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201203185
Subject(s) - materials science , silicon nanowires , circulating tumor cell , nanostructure , polymer , nanotechnology , silicon , cancer cell , nanowire , ligand (biochemistry) , biophysics , receptor , cancer , optoelectronics , metastasis , biology , biochemistry , composite material , genetics
A platform for capture and release of circulating tumor cells is demonstrated by utilizing polymer grafted silicon nanowires. In this platform, integration of ligand‐receptor recognition, nanostructure amplification, and thermal responsive polymers enables a highly efficient and selective capture of cancer cells. Subsequently, these captured cells are released upon a physical stimulation with outstanding cell viability.