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Label‐Free Polypeptide‐Based Enzyme Detection Using a Graphene‐Nanoparticle Hybrid Sensor
Author(s) -
Myung Sung,
Yin Perry T.,
Kim Cheoljin,
Park Jaesung,
Solanki Aniruddh,
Reyes Pavel Ivanoff,
Lu Yicheng,
Kim Kwang S.,
Lee KiBum
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201202961
Subject(s) - biosensor , graphene , materials science , hysteresis , nanotechnology , nanoparticle , physics , quantum mechanics
A graphene‐nanoparticle (NP) hybrid biosensor that utilizes an electrical hysteresis change to detect the enzymatic activity and concentration of Carboxypeptidase B was developed. The results indicate that the novel graphene‐NP hybrid biosensor, utilizing electrical hysteresis, has the ability to detect concentrations of targeted enzyme on the micromolar scale. Furthermore, to the knowledge of the authors, this is the first demonstration of a graphene‐based biosensor that utilizes a hysteresis change resulting from metallic NPs assembled on a graphene surface.