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Plasmid‐Templated Shape Control of Condensed DNA–Block Copolymer Nanoparticles
Author(s) -
Jiang Xuan,
Qu Wei,
Pan Deng,
Ren Yong,
Williford JohnMichael,
Cui Honggang,
Luijten Erik,
Mao HaiQuan
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201202932
Subject(s) - copolymer , materials science , polyethylene glycol , condensation , nanoparticle , dna , nanotechnology , plasmid , polymer , chemistry , organic chemistry , biochemistry , physics , composite material , thermodynamics
DNA‐containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.