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Modular ‘Click‐in‐Emulsion’ Bone‐Targeted Nanogels
Author(s) -
Heller Daniel A.,
Levi Yair,
Pelet Jeisa M.,
Doloff Joshua C.,
Wallas Jasmine,
Pratt George W.,
Jiang Shan,
Sahay Gaurav,
Schroeder Avi,
Schroeder Josh E.,
Chyan Yieu,
Zurenko Christopher,
Querbes William,
Manzano Miguel,
Kohane Daniel S.,
Langer Robert,
Anderson Daniel G.
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201202881
Subject(s) - nanogel , materials science , emulsion , surface modification , click chemistry , biodistribution , modular design , bisphosphonate , ligand (biochemistry) , nanotechnology , biomedical engineering , drug delivery , chemical engineering , polymer chemistry , chemistry , computer science , in vitro , medicine , biochemistry , osteoporosis , receptor , endocrinology , engineering , operating system
A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click‐chemistry in‐emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti‐osteoporotic effects.