Premium
Fragmentation of Poly(lactic acid) Nanosheets and Patchwork Treatment for Burn Wounds
Author(s) -
Okamura Yosuke,
Kabata Koki,
Kinoshita Manabu,
Miyazaki Hiromi,
Saito Akihiro,
Fujie Toshinori,
Ohtsubo Shinya,
Saitoh Daizoh,
Takeoka Shinji
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201202851
Subject(s) - materials science , nanotechnology , coating , nanomaterials , polymer , nanosheet , polyester , fabrication , monolayer , nanometre , layer by layer , chemical engineering , layer (electronics) , composite material , engineering , medicine , alternative medicine , pathology
Freestanding poly( L ‐lactic acid) (PLLA) nanosheets are mass‐produced by a simple combination of a spin‐coating‐assisted multi‐layering process and a peeling technique. The resulting PLLA nanosheets are fragmented by homogenization and then reconstructed into a “patchwork” sheet on various surfaces without any adhesive reagents. The patchwork is shown to offer excellent protection against burn wound infection with Pseudomonas aeruginosa , and may therefore be an alternative to conventional burn therapy for prevention of infection.