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Multicompartment Intracellular Self‐Expanding Nanogel for Targeted Delivery of Drug Cocktail
Author(s) -
Bahadur K. C. Remant,
Xu Peisheng
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201202687
Subject(s) - nanogel , intracellular , materials science , drug delivery , nanotechnology , swelling , drug , biophysics , nano , payload (computing) , pharmacology , chemistry , biochemistry , computer science , biology , composite material , computer network , network packet
A nano cocktail, NCPD, fabricated from a pH and redox dual responsive polymer shows a multicompartment structure. The NCPD nanogel is stable in physiological environments while intracellular spontaneous swelling and fast releasing its payload. NCPD displays much stronger synergism than its free drug counterpart, which suggests that NCPD could greatly attenuate the side effects of drug cocktails while boosting synergistic anticancer effects.