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Unraveling Stress‐Induced Toxicity Properties of Graphene Oxide and the Underlying Mechanism
Author(s) -
Zhang Wendi,
Wang Chi,
Li Zhongjun,
Lu Zhenzhen,
Li Yiye,
Yin JunJie,
Zhou YuTing,
Gao Xingfa,
Fang Ying,
Nie Guangjun,
Zhao Yuliang
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201202678
Subject(s) - graphene , oxidizing agent , materials science , radical , mechanism (biology) , oxide , toxicity , biophysics , nanotechnology , chemistry , biochemistry , organic chemistry , biology , metallurgy , philosophy , epistemology
Graphene oxide shows stress‐induced toxicity properties in vivo under different pathophysiological conditions. A dual‐path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.