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Measurement of Barrier Tissue Integrity with an Organic Electrochemical Transistor
Author(s) -
Jimison Leslie H,
Tria Scherrine A.,
Khodagholy Dion,
Gurfinkel Moshe,
Lanzarini Erica,
Hama Adel,
Malliaras George G.,
Owens Róisín M.
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201202612
Subject(s) - materials science , transistor , electrochemistry , paracellular transport , sensitivity (control systems) , nanotechnology , optoelectronics , electrode , voltage , electronic engineering , electrical engineering , chemistry , membrane , biochemistry , permeability (electromagnetism) , engineering
The integration of an organic electrochemical transistor with human barrier tissue cells provides a novel method for assessing toxicology of compounds in vitro. Minute variations in paracellular ionic flux induced by toxic compounds are measured in real time, with unprecedented temporal resolution and extreme sensitivity.