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A Hydrogen Peroxide‐Responsive O 2 Nanogenerator for Ultrasound and Magnetic‐Resonance Dual Modality Imaging
Author(s) -
Yang Fang,
Hu Sunling,
Zhang Yu,
Cai Xiaowei,
Huang Yan,
Wang Feng,
Wen Song,
Teng Gaojun,
Gu Ning
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201202367
Subject(s) - prussian blue , modality (human–computer interaction) , hydrogen peroxide , magnetic resonance imaging , materials science , proton magnetic resonance , nanoparticle , ultrasound , in vivo , nuclear magnetic resonance , nanotechnology , combinatorial chemistry , computer science , chemistry , electrochemistry , radiology , physics , organic chemistry , artificial intelligence , medicine , electrode , microbiology and biotechnology , biology
It is found that Prussian Blue nanoparticles (PBNPs) possess a catalase‐like activity to catalyse the breakdown of H 2 O 2 into oxygen (O 2 ) molecules under the neutral conditions (pH = 7.4). Based on this finding, we have developed a new strategy in which PBNPs can be excellent ultrasound (US) and magnetic‐resonance (MR) dual modality imaging contrast agents for H 2 O 2 diagnostics in vitro and in vivo.