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Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor
Author(s) -
Yuan YouYong,
Mao ChengQiong,
Du XiaoJiao,
Du JinZhi,
Wang Feng,
Wang Jun
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201202296
Subject(s) - nanoparticle , drug delivery , polymer , materials science , nanotechnology , drug , surface charge , chemistry , pharmacology , medicine , composite material
Two faced nanoparticles : A zwitterionic polymer‐based nanoparticle with response to tumor acidity is developed for enhanced drug delivery to tumors. The nanoparticles are neutrally charged at physiological conditions and show prolonged circulation time; after leaking into tumor sites, in the acidic extracellular tumor environment (pH e ), nanoparticles are activated and become positively charged and are therefore efficiently taken up by tumor cells, leading to enhanced therapeutic effects in cancer treatment.