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Coordination Polymer Coated Mesoporous Silica Nanoparticles for pH‐Responsive Drug Release
Author(s) -
Xing Lei,
Zheng Haoquan,
Cao Yuanyuan,
Che Shunai
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201201742
Subject(s) - materials science , mesoporous silica , nanoparticle , polymer , mesoporous material , chemical engineering , nanotechnology , drug , organic chemistry , catalysis , composite material , chemistry , engineering , psychology , psychiatry
Coordination polymer coated mesoporous silica nanoparticles for drug delivery are successfully synthesized. The system ensures that drugs are stored in the mesopores under a physiological environment. Upon H + stimulus in the endosomal and lysosomal compartments, the drugs are released into the intracellular organelles of cancer cells, effectively killing the cells.