Premium
Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross‐Linking and Their Application for Specific Cellular Imaging
Author(s) -
Yu Jiangbo,
Wu Changfeng,
Zhang Xuanjun,
Ye Fangmao,
Gallina Maria Elena,
Rong Yu,
Wu IChe,
Sun Wei,
Chan YangHsiang,
Chiu Daniel T.
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201201245
Subject(s) - covalent bond , surface modification , materials science , nanotechnology , polymer , small molecule , molecule , combinatorial chemistry , chemical engineering , chemistry , organic chemistry , biochemistry , engineering , composite material
A facile cross‐linking strategy covalently links functional molecules to semiconducting polymer dots (Pdots) while simultaneously providing functional groups for biomolecular conjugation. In addition to greatly enhanced stability, the formed Pdots are small (<10 nm), which can be difficult to achieve with current methods but is highly desirable for most biological applications. These characteristics are significant for improving labeling efficiency and sensitivity in cellular assays that employ Pdots.