Premium
Microfibers Fabricated by Non‐Covalent Assembly of Peptide and DNA for Viral Vector Encapsulation and Cancer Therapy
Author(s) -
Yang Jingye,
Balasundaram Ghayathri,
Lo SeongLoong,
Guang Eugene Choo Shi,
Xue Jun Min,
Song Jianxing,
Wan Andrew C.A.,
Ying Jackie Y.,
Wang Shu
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201201145
Subject(s) - materials science , amphiphile , microfiber , dna , peptide , covalent bond , aqueous solution , encapsulation (networking) , circular dna , self assembling peptide , nanotechnology , biophysics , biochemistry , organic chemistry , chemistry , genome , composite material , biology , gene , nanofiber , polymer , copolymer , computer network , computer science
Self‐assembled amphiphilic peptide units and supercoiled, circular double‐stranded plasmid DNA are used as building blocks to form peptide/DNA fibers for virus encapsulation. Since the fiber formation process takes place under ambient conditions and is aqueous‐based without the use of denaturing organic solvents, the bioactivity of viruses is well preserved.