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Molecular Engineered Super‐Nanodevices: Smart and Safe Delivery of Potent Drugs into Tumors
Author(s) -
Ding Mingming,
Li Jiehua,
He Xueling,
Song Nijia,
Tan Hong,
Zhang Yi,
Zhou Lijuan,
Gu Qun,
Deng Hua,
Fu Qiang
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201200954
Subject(s) - nanodevice , nanotechnology , triptolide , computer science , drug delivery , materials science , chemistry , biochemistry , apoptosis
A super‐nanodevice engineered at molecular level integrates various desired properties in a smart and coordinated way, and can “switch on” or “turn off” certain functionalities as required. Importantly, it can break through complex physiological barriers, and then precisely ferry potent toxic triptolide into tumor cells in vivo, thus significantly maximizing the therapeutic efficacy and reducing the drug toxicity.