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A 3D Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers
Author(s) -
Bellan Leon M.,
Pearsall Matthew,
Cropek Donald M.,
Langer Robert
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201200810
Subject(s) - gelatin , microfiber , materials science , shellac , dissolution , polymer science , microfluidics , aqueous solution , solubility , microchannel , inkwell , nanotechnology , chemical engineering , composite material , organic chemistry , chemistry , engineering , coating
3D microfluidic networks are fabricated in a gelatin hydrogel using sacrificial melt‐spun microfibers made from a material with pH‐dependent solubility. The fibers, after being embedded within the gel, can be removed by changing the gel pH to induce dissolution. This process is performed in an entirely aqueous environment, avoiding extreme temperatures, low pressures, and toxic organic solvents.