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Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration
Author(s) -
Tan Justin,
Wang Yajun,
Yip Xiaopei,
Glynn Fergal,
Shepherd Robert K.,
Caruso Frank
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201200634
Subject(s) - nanoporous , materials science , neurotrophin , brain derived neurotrophic factor , mesoporous silica , neurotrophic factors , cochlea , neurodegeneration , peptide , mesoporous material , neuroscience , biophysics , nanotechnology , biochemistry , biology , medicine , receptor , catalysis , disease
Neurotrophin‐BDNF can be effectively encapsulated in nanoporous poly(L‐glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.