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Tomography and Static‐Mechanical Properties of Adherent Cells
Author(s) -
Soh Siowling,
KandereGrzybowska Kristiana,
Mahmud Goher,
Huda Sabil,
Patashinski Alexander Z.,
Grzybowski Bartosz A.
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201200492
Subject(s) - nucleus , materials science , actin , tomography , membrane , computed tomography , cell , biophysics , computer science , biological system , nanotechnology , biology , physics , neuroscience , optics , microbiology and biotechnology , biochemistry , medicine , radiology
A tomography approach is used to reconstruct 3D cell shapes and, simultaneously, the shapes/positions of the nuclei within these cells. Subjecting the cells to well‐defined microconfinements of various diameters allow for relating the steady‐state shapes of cells to their static‐mechanical properties. The observed shapes show striking regularities between different cell types and all fit to a model that takes into account the cell membrane, cortical actin, and the nucleus.