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Self‐Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T‐Cell Epitope Promote a Protective Immune Response In Vivo
Author(s) -
Black Matthew,
Trent Amanda,
Kostenko Yulia,
Lee Joseph Saeyong,
Olive Colleen,
Tirrell Matthew
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201200209
Subject(s) - cytotoxic t cell , micelle , epitope , amphiphile , peptide , in vivo , materials science , immune system , cytotoxicity , biophysics , microbiology and biotechnology , in vitro , antigen , biology , biochemistry , chemistry , immunology , organic chemistry , copolymer , aqueous solution , composite material , polymer
A model cytotoxic T‐cell epitope is linked to a synthetic lipid tail, forming a peptide amphiphile that self‐assembles into cylindrical micelles. The micelles are capable of inducing a cytotoxic T‐cell response in mice that slows the growth of tumors expressing the tumor antigen.