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Electrospun TiO 2 Nanofiber‐Based Cell Capture Assay for Detecting Circulating Tumor Cells from Colorectal and Gastric Cancer Patients
Author(s) -
Zhang Nangang,
Deng Yuliang,
Tai Qidong,
Cheng Boran,
Zhao Libo,
Shen Qinglin,
He Rongxiang,
Hong Longye,
Liu Wei,
Guo Shishang,
Liu Kan,
Tseng HisanRong,
Xiong Bin,
Zhao XingZhong
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201200155
Subject(s) - nanofiber , circulating tumor cell , materials science , substrate (aquarium) , extracellular matrix , nanotechnology , colorectal cancer , tumor cells , cell , matrix (chemical analysis) , cancer , cancer research , composite material , microbiology and biotechnology , biology , biochemistry , medicine , ecology , metastasis
A nanostructured platform that combines electrospun TiO 2 nanofibers (TiNFs)‐deposited substrate and cell‐capture agent realizes significant capture of circulating tumor cells (CTCs). The enhanced local topographic interactions between the horizontally packed TiNFs deposited substrates and extracellular matrix scaffolds, in addition to anti‐EpCAM/EpCAM biological recognition, contributes to the significantly enhanced capture efficiency compared to flat surfaces.