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Osteophilic Multilayer Coatings for Accelerated Bone Tissue Growth
Author(s) -
Shah Nisarg J.,
Hong Jinkee,
Hyder Md. Nasim,
Hammond Paula T.
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201104475
Subject(s) - mesenchymal stem cell , materials science , chitosan , coating , polymer , bone tissue , modular design , biomedical engineering , nanotechnology , microbiology and biotechnology , biochemistry , computer science , composite material , biology , medicine , operating system
Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly( β ‐amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.