Premium
Hierarchical Formation of Supramolecular Transient Networks in Water: A Modular Injectable Delivery System
Author(s) -
Dankers Patricia Y. W.,
Hermans Thomas M.,
Baughman Travis W.,
Kamikawa Yuko,
Kieltyka Roxanne E.,
Bastings Maartje M. C.,
Janssen Henk M.,
Sommerdijk Nico A. J. M.,
Larsen Antje,
van Luyn Marja J. A.,
Bosman Anton W.,
Popa Eliane R.,
Fytas George,
Meijer E. W.
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201104072
Subject(s) - ethylene glycol , materials science , supramolecular chemistry , modular design , polymer , transient (computer programming) , hydrogen bond , chemical engineering , dissolution , supramolecular assembly , nanotechnology , molecule , computer science , organic chemistry , chemistry , composite material , engineering , operating system
A modular one‐component supramolecular transient network in water, based on poly(ethylene glycol) and end‐capped with four‐fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.