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Design of Multifunctional Micelle for Tumor‐Targeted Intracellular Drug Release and Fluorescent Imaging
Author(s) -
Wang Weiwei,
Cheng Du,
Gong Faming,
Miao Xiangmin,
Shuai Xintao
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201104066
Subject(s) - micelle , fluorescence , materials science , nanotechnology , drug delivery , in vivo , drug , surface modification , biophysics , combinatorial chemistry , chemistry , organic chemistry , pharmacology , biology , physics , microbiology and biotechnology , quantum mechanics , aqueous solution
A novel multifunctional polymeric micelle bearing a pH‐tunable on‐off module for programmed drug release, folate for tumor targeting, and quantum dots for fluorescent imaging is described. The micelle can turn drug release off at neutral pH whereas on inside lysosomes. QD functionalization allows a clear elucidation of pH‐tunable drug release and facile visualization of in vivo delivery event.