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Perfluorohexane‐Encapsulated Mesoporous Silica Nanocapsules as Enhancement Agents for Highly Efficient High Intensity Focused Ultrasound (HIFU)
Author(s) -
Wang Xia,
Chen Hangrong,
Chen Yu,
Ma Ming,
Zhang Kun,
Li Faqi,
Zheng Yuanyi,
Zeng Deping,
Wang Qi,
Shi Jianlin
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201104033
Subject(s) - high intensity focused ultrasound , materials science , nanocapsules , coagulative necrosis , mesoporous silica , in vivo , nanotechnology , nanoparticle , mesoporous material , ultrasound , ablation , biomedical engineering , radiology , catalysis , organic chemistry , chemistry , medicine , microbiology and biotechnology , pathology , biology
An inorganic enhancement agent (EA) for high‐intensity focused ultrasound (HIFU) imaging based on mesoporous silica nanocapsules is presented. The pronounced coagulative necrosis effects demonstrate, both in vitro and in vivo, that the EA can be developed as a highly promising theranostic agent for effective HIFU imaging and therapy owing to its high stability, efficient perfluorohexane loading and release, enhanced tumor ablation capability, and easy uptake by target tissues.