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Carbon Nanotubes Induce Bone Calcification by Bidirectional Interaction with Osteoblasts
Author(s) -
Shimizu Masayuki,
Kobayashi Yasuhiro,
Mizoguchi Toshihide,
Nakamura Hiroaki,
Kawahara Ichiro,
Narita Nobuyo,
Usui Yuki,
Aoki Kaoru,
Hara Kazuo,
Haniu Hisao,
Ogihara Nobuhide,
Ishigaki Norio,
Nakamura Koichi,
Kato Hiroyuki,
Kawakubo Masatomo,
Dohi Yoshiko,
Taruta Seiichi,
Kim Yoong Ahm,
Endo Morinobu,
Ozawa Hidehiro,
Udagawa Nobuyuki,
Takahashi Naoyuki,
Saito Naoto
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201103832
Subject(s) - materials science , calcification , carbon nanotube , osteoblast , nanotechnology , carbon fibers , composite material , medicine , biochemistry , in vitro , biology , composite number
Multi‐walled carbon nanotubes (MWCNTs) promote calcification during hydroxyapatite (HA) formation by osteoblasts. Primary cultured osteoblasts are incubated with MWCNTs or carbon black. After culture for 3 weeks, the degree of calcification is very high in the 50 μg mL −1 MWCNT group. Transmission electron microscopy shows needle‐like crystals around the MWCNTs, and diffraction patterns reveal that the peak of the crystals almost coincides with the known peak of HA.