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Plasmonic Nanobubbles Enhance Efficacy and Selectivity of Chemotherapy Against Drug‐Resistant Cancer Cells
Author(s) -
LukianovaHleb Ekaterina Y.,
Ren Xiaoyang,
Zasadzinski Joseph A.,
Wu Xiangwei,
Lapotko Dmitri O.
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201103550
Subject(s) - materials science , cancer cell , plasmon , drug delivery , drug , intracellular , drug resistance , nanotechnology , cancer , chemotherapeutic drugs , plasmonic nanoparticles , biophysics , microbiology and biotechnology , pharmacology , medicine , biology , optoelectronics
Plasmonic nanobubbles, new multifunctional cellular nano‐agents , are selectively generated in target cancer cells with a short near‐infrared laser pulse. The enhanced cellular specificity and tunable transient nature of plasmonic nanobubbles provide fast, efficient and selective dual therapeutic effects: intracellular delivery of a drug and direct mechanical destruction of cells while sparing normal cells, and reduce drug dose and overcome drug‐resistance of cancer cells.