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Magnetic Nanocarriers with Tunable pH Dependence for Controlled Loading and Release of Cationic and Anionic Payloads
Author(s) -
Bigall Nadja C.,
Curcio Alberto,
Leal Manuel Pernia,
Falqui Andrea,
Palumberi Domenico,
Di Corato Riccardo,
Albanesi Ennio,
Cingolani Roberto,
Pellegrino Teresa
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201103505
Subject(s) - nanocarriers , cationic polymerization , superparamagnetism , materials science , nanotechnology , adsorption , surface charge , nanoparticle , chemical engineering , combinatorial chemistry , chemistry , organic chemistry , polymer chemistry , physics , magnetization , quantum mechanics , magnetic field , engineering
Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co‐precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.