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Shrink‐Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives
Author(s) -
Chen Aaron,
Lieu Deborah K.,
Freschauf Lauren,
Lew Valerie,
Sharma Himanshu,
Wang Jiaxian,
Nguyen Diep,
Karakikes Ioannis,
Hajjar Roger J.,
Gopinathan Ajay,
Botvinick Elliot,
Fowlkes Charless C.,
Li Ronald A.,
Khine Michelle
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201103463
Subject(s) - materials science , embryonic stem cell , substrate (aquarium) , nanotechnology , stem cell , biomimetic materials , biomedical engineering , microbiology and biotechnology , biology , biochemistry , medicine , ecology , gene
A biomimetic substrate for cell‐culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment “wrinkles”. Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.