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Physically Associated Synthetic Hydrogels with Long‐Term Covalent Stabilization for Cell Culture and Stem Cell Transplantation
Author(s) -
Zhang Jianjun,
Tokatlian Talar,
Zhong Jin,
Ng Quinn K. T.,
Patterson Michaela,
Lowry William E.,
Carmichael S. Thomas,
Segura Tatiana
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201103349
Subject(s) - self healing hydrogels , ethylene glycol , peg ratio , covalent bond , materials science , transplantation , tissue engineering , in vitro , cell culture , nanotechnology , polymer chemistry , chemistry , biomedical engineering , biochemistry , organic chemistry , biology , medicine , surgery , finance , economics , genetics
Poly(ethylene glycol)‐poly(propylene sulfide) (PEG‐PPS) hydrogels are injectable synthetic non‐protease degradable hydrogels that allow cell spreading and proliferation in vitro and cellular infiltration in vivo. Further, this hydrogel promotes the survival of transplanted neural progenitor cells in the brain. PEG‐PPS hydrogels form through a combination of hydrophobic interactions between the PPS domains and covalent bonds through disulfide exchange reactions of the polymer end groups.