Premium
Kinetically Assembled Nanoparticles of Bioactive Macromolecules Exhibit Enhanced Stability and Cell‐Targeted Biological Efficacy
Author(s) -
York Adam W.,
Zablocki Kyle R.,
Lewis Daniel R.,
Gu Li,
Uhrich Kathryn E.,
Prud'homme Robert K.,
Moghe Prabhas V.
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201103348
Subject(s) - chemistry
Kinetically assembled nanoparticles are fabricated from an advanced class of bioactive macromolecules that have potential utility in counteracting atherosclerotic plaque development via receptor‐level blockage of inflammatory cells. In contrast to micellar analogs that exhibit poor potency and structural integrity under physiologic conditions, these kinetic nanoparticle assemblies maintain structural stability and demonstrate superior bioactivity in mediating oxidized low‐density lipoprotein (oxLDL) uptake in inflammatory cells.