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“Living” Microvascular Stamp for Patterning of Functional Neovessels; Orchestrated Control of Matrix Property and Geometry
Author(s) -
Jeong Jae Hyun,
Chan Vincent,
Cha Chaenyung,
Zorlutuna Pinar,
Dyck Casey,
Hsia K. Jimmy,
Bashir Rashid,
Kong Hyunjoon
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201103207
Subject(s) - engraving , matrix (chemical analysis) , materials science , microbiology and biotechnology , secretion , angiogenesis , property (philosophy) , nanotechnology , biology , cancer research , biochemistry , composite material , philosophy , epistemology
This study presents a “living” microvascular stamp that releases multiple angiogenic factors and subsequently creates functional neovessels with the same pattern as that engraved in the stamp. The stamp consists of live cells that secrete angiogenic factors, an engineered hydrogel matrix that promotes cellular expression of angiogenic factors, and a three‐dimensional geometry that localizes the angiogenic factors within the pattern.