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Detection of a Prognostic Indicator in Early‐Stage Cancer Using Functionalized Graphene‐Based Peptide Sensors
Author(s) -
Feng Lingyan,
Wu Li,
Wang Jiasi,
Ren Jinsong,
Miyoshi Daisuke,
Sugimoto Naoki,
Qu Xiaogang
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201103205
Subject(s) - graphene , materials science , nanotechnology , electrochemistry , peptide , electrode , cancer , stage (stratigraphy) , cancer therapy , electrochemical gas sensor , combinatorial chemistry , cancer research , computer science , medicine , biochemistry , chemistry , biology , paleontology
Using a porphyrin‐functionalized graphene‐modified electrode , an electrochemical impedance peptide sensor for label‐free detection of cyclin A 2 has been constructed. This electrochemical sensor can not only detect protein in cancer cells but also differentiate cancer cells from normal ones. Furthermore, the assay provides the potential of using a simple electrochemical technique to estimate the efficiency of anticancer drugs in cancer therapy.