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Surfaces That Sequester Serum‐Borne Heparin Amplify Growth Factor Activity
Author(s) -
Hudalla Gregory A.,
Koepsel Justin T.,
Murphy William L.
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201103046
Subject(s) - heparin , covalent bond , fetal bovine serum , growth factor , materials science , peptide , biophysics , cell , biochemistry , chemistry , biology , organic chemistry , receptor
Surfaces presenting a heparin‐binding peptide can non‐covalently sequester heparin from culture supplements , such as fetal bovine serum. In turn, sequestered, serum‐borne heparin can non‐covalently localize growth factors at the cell‐material interface, resulting in amplified growth factor bioactivity.