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Microdrop Printing of Hydrogel Bioinks into 3D Tissue‐Like Geometries
Author(s) -
Pataky Kris,
Braschler Thomas,
Negro Andrea,
Renaud Philippe,
Lutolf Matthias P.,
Brugger Juergen
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201102800
Subject(s) - self healing hydrogels , materials science , structuring , nanotechnology , 3d printing , microfluidics , inkjet printing , process (computing) , tissue engineering , inkwell , biomedical engineering , composite material , polymer chemistry , computer science , medicine , finance , economics , operating system
An optimized 3D inkjet printing process is demonstrated for structuring alginate into a tissue‐like microvasculature capable of supporting physiological flow rates. Optimizing the reaction at the single‐droplet level enables wet hydrogel droplets to be stacked, thus overcoming their natural tendancy to spread and coalesce. Live cells can be patterned using this process and it can be extended to a range of other hydrogels.