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Efficient Delivery of Gold Nanoparticles by Dual Receptor Targeting
Author(s) -
Bhattacharyya Sanjib,
Khan Jameel Ahmad,
Curran Geoffry L.,
Robertson J. David,
Bhattacharya Resham,
Mukherjee Priyabrata
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201102287
Subject(s) - folate receptor , epidermal growth factor receptor , colloidal gold , materials science , receptor , nanotechnology , cancer cell , cancer research , cancer , nanoparticle , chemistry , biology , medicine , biochemistry
The fabrication and characterization of a dual receptor targeted system (DRTS) are described. It is demonstrated that DRTS is more efficient at delivering gold nanoparticles (AuNPs) to ovarian cancer cells expressing epidermal growth factor receptor (EGFR) and folate receptor (FR) than their corresponding single‐receptor‐targeting systems (SRTS).