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Multimodal Nanodiamond Drug Delivery Carriers for Selective Targeting, Imaging, and Enhanced Chemotherapeutic Efficacy
Author(s) -
Zhang XueQing,
Lam Robert,
Xu Xiaoyang,
Chow Edward K.,
Kim HoJoong,
Ho Dean
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201102263
Subject(s) - nanodiamond , internalization , oligonucleotide , conjugate , drug delivery , moiety , materials science , nanotechnology , intracellular , biophysics , monoclonal antibody , combinatorial chemistry , chemistry , biochemistry , dna , cell , biology , stereochemistry , genetics , diamond , composite material , mathematical analysis , mathematics , antibody
Multimodal nanodiamonds (NDs) were prepared by attaching fluorescently labeled drug‐oligonucleotide conjugates and monoclonal antibodies onto the ND surface. Fluorescently labeled oligonucleotide linkers enabled the intracellular observation and quantification of resultant ND conjugates. The covalent attachment of the chemotherapeutic and targeting moiety to the ND surface significantly enhanced cellular internalization and therapeutic activity