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Choline‐Derivate‐Modified Nanoparticles for Brain‐Targeting Gene Delivery
Author(s) -
Li Jianfeng,
Zhou Lu,
Ye Deyong,
Huang Shixian,
Shao Kun,
Huang Rongqin,
Han Liang,
Liu Yang,
Liu Shuhuan,
Ye Liya,
Lou Jinning,
Jiang Chen
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201101899
Subject(s) - choline , gene delivery , nanoparticle , in vivo , transporter , in vitro , materials science , nanotechnology , computational biology , gene , biophysics , biochemistry , biology , genetic enhancement , genetics
The choline transporter (ChT) is used to transporte choline‐derivate‐modified nanoparticles across the blood‐brain barrier. It is demonstrated that ChT is an ideal Trojan horse. The choline‐derivate‐modified nanoparticles exhibit higher permeability across the brain capillary endothelial cells (BCECs) monolayer in vitro and higher gene distribution and expression in vivo.