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Reversible Tuning of SERS Hot Spots with Aptamers
Author(s) -
Kim Nam Hoon,
Lee Seung Joon,
Moskovits Martin
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201101847
Subject(s) - aptamer , surface enhanced raman spectroscopy , nanotechnology , materials science , event (particle physics) , raman spectroscopy , molecule , computer science , optics , chemistry , physics , raman scattering , biology , organic chemistry , genetics , quantum mechanics
A reversible surface‐enhanced Raman spectroscopy (SERS)‐based sensor with stem loop aptamers is reported. It is capable of detecting its target molecule at concentrations below the micromolar level and of delivering robust signals from events involving fewer than ten target molecules. Washing the sensor with buffer causes the SERS spectrum to revert to its pre‐detection‐event form, fully restoring its capability as a sensor.