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Controlled Protein Delivery Based on Enzyme‐Responsive Nanocapsules
Author(s) -
Wen Jing,
Anderson Sean M.,
Du Juanjuan,
Yan Ming,
Wang Jun,
Shen Meiqing,
Lu Yunfeng,
Segura Tatiana
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201101771
Subject(s) - nanocapsules , nanotechnology , enzyme , materials science , computational biology , biology , biochemistry , nanoparticle
Enzyme‐responsive protein nanocapsules are synthesized to release their protein cargoes in response to specific enzymes secreted in certain cellular events with both specificity and with a controlled rate by composition tuning. The unique nanocapsule structures protect the encapsulated proteins during hydrogel synthesis, providing a new direction for responsive protein delivery according to specific cellular events or the local environment.