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Cellular Association and Cargo Release of Redox‐Responsive Polymer Capsules Mediated by Exofacial Thiols
Author(s) -
Yan Yan,
Wang Yajun,
Heath Joan K.,
Nice Edouard C.,
Caruso Frank
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201101609
Subject(s) - redox , disulfide bond , polymer , materials science , nanotechnology , layer (electronics) , mesoporous silica , chemical engineering , mesoporous material , combinatorial chemistry , polymer science , chemistry , organic chemistry , biochemistry , composite material , engineering , metallurgy , catalysis
Redox‐responsive polymer capsules stabilized by disulfide bonds and loaded with hydrophobic cargo are prepared by templating mesoporous silica particles via layer‐by‐layer assembly. The thiols and disulfide bonds in the capsules interact with the exofacial thiols on the cell membrane, which regulate cellular association and cargo release from the capsules.