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E‐Selectin‐Targeted Porous Silicon Particle for Nanoparticle Delivery to the Bone Marrow
Author(s) -
Mann Aman P.,
Tanaka Takemi,
Somasunderam Anoma,
Liu Xuewu,
Gorenstein David G.,
Ferrari Mauro
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201101541
Subject(s) - materials science , porous silicon , drug delivery , nanoparticle , payload (computing) , nanotechnology , particle (ecology) , targeted drug delivery , porosity , ligand (biochemistry) , silicon , bone marrow , computer science , medicine , composite material , optoelectronics , pathology , receptor , computer network , oceanography , network packet , geology
A multifunctional drug delivery system is developed comprising biodegradable porous silicon microparticles that act as motherships to ferry different types of imaging and therapeutic nanoparticles loaded within their porous structure. An E‐selectin thioaptamer ligand is used to actively target this delivery system to the bone marrow vasculature where the payload is released as the porous silicon underwent degradation under physiological conditions.