Direct Electrical Measurement of Protein–Water Interactions and Temperature Dependence Using Piezoelectric Microcantilevers | Zendy

Lee Jeong Hoon | Zendy; Hwang Kyo Seon | Zendy; Yoon Dae Sung | Zendy; Kang Ji Yoon | Zendy; Kim Sang Kyung | Zendy; Kim Tae Song | Zendy

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Direct Electrical Measurement of Protein–Water Interactions and Temperature Dependence Using Piezoelectric Microcantilevers

Author(s) -

Lee Jeong Hoon,

Hwang Kyo Seon,

Yoon Dae Sung,

Kang Ji Yoon,

Kim Sang Kyung,

Kim Tae Song

Publication year - 2011

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201101037

Subject(s) - materials science , monoclonal antibody , piezoelectricity , humidity , protein–protein interaction , biophysics , chemical physics , biological system , antibody , thermodynamics , composite material , biology , chemistry , microbiology and biotechnology , physics , immunology

A platform that provides a fundamental tool to understand protein behaviors by a simple real‐time electrical readout is demonstrated. Observing the temperature dependence of protein activity as well as the humidity‐sensitive protein activity of a prostate‐specific antigen (PSA) monoclonal antibody receptor (MAbs), as well as PSA–MAbs receptor complexes, provides a stability curve for the protein and a humidity dependence of their activity.

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