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Synthesis and Radioluminescence of PEGylated Eu 3+ ‐doped Nanophosphors as Bioimaging Probes
Author(s) -
Sun Conroy,
Pratx Guillem,
Carpenter Colin M.,
Liu Hongguang,
Cheng Zhen,
Gambhir Sanjiv Sam,
Xing Lei
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201100919
Subject(s) - radioluminescence , materials science , lanthanide , biological imaging , fluorescence , luminescence , autofluorescence , optoelectronics , photon upconversion , stokes shift , quantum dot , doping , near infrared spectroscopy , photon , fluorescence lifetime imaging microscopy , nanotechnology , optics , scintillator , chemistry , detector , physics , ion , organic chemistry
Lanthanide‐doped nanophosphors stimulated by high‐energy photons or β + ‐particles display characteristic 590, 615, and 692 nm emissions of the Eu 3+ activator. These radioluminescent nanophosphors, produced by a thermo degradation process and coated with poly(ethylene glycol), serve as imaging probes as demonstrated in vivo with matrigel inclusions detected by both a custom X‐ray luminescence and a conventional small animal optical imaging system.