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Dynamic Topographical Control of Mesenchymal Stem Cells by Culture on Responsive Poly(ϵ‐caprolactone) Surfaces
Author(s) -
Le Duy M.,
Kulangara Karina,
Adler Andrew F.,
Leong Kam W.,
Ashby Valerie Sheares
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201100821
Subject(s) - caprolactone , materials science , mesenchymal stem cell , shape memory polymer , characterization (materials science) , surface modification , morphology (biology) , polymer , nanotechnology , chemical engineering , microbiology and biotechnology , composite material , biology , polymerization , genetics , engineering
Poly(ϵ‐caprolactone) (PCL) shape‐memory polymer (SMP) microarrays are a novel means to investigate the effect of dynamic topography on human mesenchymal stem cell (hMSC) morphology. The synthesis and characterization of oligo‐precursors and PCL networks is described. The PCL surfaces demonstrate excellent surface shape‐memory properties, minimal cytotoxicity, and excellent control over hMSC morphology.