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Facile Engineering of Biocompatible Materials with pH‐Modulated Degradability
Author(s) -
Zhang Jianxiang,
Jia Yi,
Li Xiaodong,
Hu Yingqian,
Li Xiaohui
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201100679
Subject(s) - biocompatible material , materials science , polymer , nanotechnology , hydrolysis , cyclodextrin , chemical engineering , organic chemistry , composite material , chemistry , biomedical engineering , medicine , engineering
Facile synthesis of biocompatible materials from α‐ or β‐cyclodextrin and their polymers can be achieved via a kinetically controlled acetalation. These materials can hydrolyze into the corresponding precursors, with a fast or slow process dependent on pH. Since cyclodextrins can function as the building units to synthesize polymers with great structural diversity, the methodology developed herein may be a facile but powerful approach to create a materials library with wide biomedical applications.