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Hydrophobic Shell Loading of Biopolyelectrolyte Capsules
Author(s) -
Cui Di,
Jing Jing,
Boudou Thomas,
PignotPaintrand Isabelle,
De Koker Stefaan,
De Geest Bruno G.,
Picart Catherine,
AuzélyVelty Rachel
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201100600
Subject(s) - nanoshell , materials science , molecule , layer (electronics) , hyaluronic acid , chitosan , shell (structure) , nanotechnology , derivative (finance) , combinatorial chemistry , chemical engineering , organic chemistry , chemistry , nanoparticle , composite material , biology , financial economics , engineering , economics , genetics
A versatile method to selectively encapsulate water‐insoluble molecules in the nanoshell of layer‐by‐layer capsules made exclusively of polysaccharides is described. This relies on the very high affinity of hydrophobic molecules for an alkylated hyaluronic acid used as a polyanionic partner of a chitosan derivative for the capsule synthesis. The hydrophobic molecules entrapped in the nanoshell can be delivered intracellularly in dendritic cells.