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pH‐Triggered Drug‐Releasing Magnetic Nanoparticles for Cancer Therapy Guided by Molecular Imaging by MRI
Author(s) -
Lim EunKyung,
Huh YongMin,
Yang Jaemoon,
Lee Kwangyeol,
Suh JinSuck,
Haam Seungjoo
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201100351
Subject(s) - nanocarriers , materials science , magnetic resonance imaging , nanoparticle , magnetic nanoparticles , drug , doxorubicin , nanotechnology , molecular imaging , cancer therapy , drug delivery , cancer treatment , cancer , biomedical engineering , pharmacology , medicine , chemotherapy , in vivo , radiology , microbiology and biotechnology , biology
pH‐sensitive drug‐delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.