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Stem Cells: Patterned Differentiation of Individual Embryoid Bodies in Spatially Organized 3D Hybrid Microgels (Adv. Mater. 46/2010)
Author(s) -
Qi Hao,
Du Yanan,
Wang Lianyong,
Kaji Hirokazu,
Bae Hojae,
Khademhosseini Ali
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201090153
Subject(s) - embryoid body , materials science , nanotechnology , stem cell , biophysics , cellular differentiation , microbiology and biotechnology , adult stem cell , biology , biochemistry , gene
A microengineered hybrid hydrogel containing asymmetrical extracellular matrices is developed to mimic anisotropic stem cell niches, in work reported by Ali Khademhosseini and co‐workers on p. 5276. The reconstructed artificial asymmetrical extracellular matrix enables thorough investigation of spatially regulated embryonic development without exogenous factors. This technique may be a powerful platform for further understanding and engineering of stem cells in controlled environments.