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Drug Delivery: Nano‐Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA (Adv. Mater. 43/2010)
Author(s) -
DeMuth Peter C.,
Su Xingfang,
Samuel Raymond E.,
Hammond Paula T.,
Irvine Darrell J.
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201090139
Subject(s) - materials science , drug delivery , nanotechnology , polymer , nanoparticle , drug , biodegradable polymer , drug carrier , composite material , pharmacology , medicine
A new strategy to create biodegradable drug‐loaded coatings on microneedle patches, using a process known as layer‐by‐layer (LbL) self‐assembly, is reported on p. 4851 by Paula Hammond and coworkers. Water‐soluble polymers are adsorbed with oppositely‐charged drugs or drug‐carrying polymer particles in alternating layers, creating extremely thin coatings loaded with high levels of entrapped drugs. These biodegradable films can be used to deposit DNA or drug‐carrier nanoparticles into the skin, representing model drug cargos that could be used for vaccination or other therapeutic drug delivery.