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Elastic 3D Scaffolds: Elastic Fully Three‐dimensional Microstructure Scaffolds for Cell Force Measurements (Adv. Mater. 8/2010)
Author(s) -
Klein Franziska,
Striebel Thomas,
Fischer Joachim,
Jiang Zhongxiang,
Franz Clemens M.,
von Freymann Georg,
Wegener Martin,
Bastmeyer Martin
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201090016
Subject(s) - materials science , scaffold , stiffness , microstructure , fabrication , composite material , tissue engineering , nanotechnology , biomedical engineering , medicine , alternative medicine , pathology
Martin Bastmeyer and co‐workers report on p. 868 the fabrication of elastic structures with submicrometer thickness for cell culture that can be deformed by forces exerted by single cardiomyocytes. The cover illustrates a 3D reconstruction of cardiomyocytes labeled for f‐actin (green) and a‐actinin (red) growing in an Ormocomp scaffold consisting of posts connected by flexible beams. This method offers the possibility to study cell behavior in a 3D environment with defined geometries and physiologically‐relevant stiffness values. Cover artwork by M.S. Rill.