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Rational Molecular Design of Stimulus‐Responsive Supramolecular Hydrogels Based on Dipeptides
Author(s) -
Ikeda Masato,
Tanida Tatsuya,
Yoshii Tatsuyuki,
Hamachi Itaru
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201004658
Subject(s) - supramolecular chemistry , self healing hydrogels , rational design , nanotechnology , materials science , nanobiotechnology , nanofiber , dipeptide , glucose oxidase , design elements and principles , computer science , combinatorial chemistry , peptide , biosensor , chemistry , biochemistry , molecule , organic chemistry , nanoparticle , polymer chemistry , software engineering
Stimuli‐responsive supramolecular hydrogels comprising self‐assembled nanofiber networks are attractive soft materials because of their potential application in materials science and bionanotechnology. Here, we describe a general strategy for the rational design of stimuli (redox‐ or photo‐)responsive supramolecular hydrogelators by introducing stimuli‐triggered degradation units into the N‐terminal of a dipeptide. We also demonstrate that its coupling with glucose oxidase allows us to produce a glucose‐responsive insulin‐releasing gel matrix.